Sildenafil is an active ingredient that belongs to the class of phosphodiesterase type 5 (PDE5) inhibitors. It’s highly renowned for its usage against erectile dysfunction, so much so that the active ingredient is frequently and gladly referred to by the trade name of one of the most well-known drugs that contains it: Kamagra. However, not everyone is aware that Sildenafil is also used to treat pulmonary hypertension.

Sildenafil Citrate is responsible for potent inhibitory action of phosphodiesterase type 5 (PDE5). It is an enzyme responsible for the degradation of cyclic GMP (cyclic guanosine monophosphate or GMPc), a compound involved in smooth muscle relaxation, which allows easy flow of blood to the penis tissue, thereby enhancing erection.

The sildenafil-containing medicine indicated in the treatment of pulmonary hypertension are available in the form of coated tablets, solution for injection and powder for oral suspension. In order to be sold, these medicines need to be presented with a repeatable medical prescription.

Examples of Medicines containing Sildenafil

  • Kamagra
  • Balcoga
  • Blugral
  • Viagra
  • Granpidam

Therapeutic indications of Sildenafil: what is it used for?

As mentioned, Sildenafil can be used – at the appropriate dosages – in the treatment of completely different disorders. More in detail, the active principle is indicated in:

  • Treatment of men with erectile dysfunction ( impotence );
  • Treatment of adults, children and adolescents 1 to 17 years of age with pulmonary arterial hypertension

What you need to know before taking Sildenafil for the treatment of Erectile Dysfunction

Before starting to take Sildenafil to combat erectile dysfunction you need to tell your doctor if have any of these conditions:

  • Leukemia,
  • Multiple myeloma,
  • Sickle cell anemia,
  • Penile deformities or Peyronie’s disease,
  • Heart related problems.

Finally, we would like to point out that sexual stimulation is required for Sildenafil treatment to be effective. It’s not aphrodisiac, so sexual stimulation is always needed.

Pharmacological Interactions between Sildenafil and Other Drugs

Before you start taking Sildenafil for the treatment of both erectile dysfunction and pulmonary hypertension, you should tell your doctor if you are taking:

  • Nitrate drugs, as the combination with Sildenafil can cause a dangerous lowering of blood pressure;
  • Protease inhibitor drugs for the treatment of HIV infections ;
  • Nitric oxide donor drugs (such as amyl nitrite), as again, the combination with Sildenafil can cause an excessive drop in blood pressure;
  • Riociguat (a drug used to treat pulmonary hypertension);
  • Alpha-blocker drugs to treat hypertension or enlarged prostate as some patients who have taken similar drugs and Sildenafil have developed symptoms that can be attributed to a drop in blood pressure, such as dizziness and light-headedness.

What Unwanted Effects can Sildenafil cause?

Sildenafil, like any other drug, can induce a variety of side effects, which not all individuals will experience or will experience in the same way. In reality, each individual reacts subjectively to drug administration, manifesting unpleasant effects of varying form and strength, or not manifesting them at all.

Only a few of the major negative effects that may occur while taking Sildenafil for the treatment of erectile dysfunction and pulmonary hypertension are included here. Please read the package leaflet of the drug to be taken carefully for more thorough and specific information.

Possible Side Effects of Sildenafil

The use of Sildenafil should be stopped immediately and the doctor contacted immediately if:

  • Allergic reactions which can occur with difficulty in breathing, wheezing, dizziness, swelling of the eyelids, face, tongue and throat.
  • Chest pain. If this symptom occurs after sexual intercourse, get into a semi-sitting position and try to relax.
  • Prolonged and painful erections (fortunately, generally rare).
  • Severe skin reactions.
  • Convulsions and seizures.

When and How Much Sildenafil to Take

Sildenafil for the treatment of erectile dysfunction is available in medicines for oral use (orodispersible film, coated and orodispersible tablets, chewable tablets); while for the treatment of pulmonary hypertension, Sildenafil is available in medicines for oral use (coated tablets, powder for oral suspension) and for parenteral use (solution for injection).

The type of medication to be utilized differs depending on the therapeutic indication for which Sildenafil is required. The dosage will be determined by the doctor for each patient (in the case of Sildenafil in the treatment of pulmonary hypertension, the doses may also vary depending on the patient’s age), so it is very important to follow your doctor’s recommendations.

Regarding the correct way to use the different types of Sildenafil medicines, it is once again recommended to follow the doctor ‘s instructions and to follow the instructions on the package insert of the Sildenafil medicine to be used.

How to Buy Sildenafil

The easiest way to get Sildenafil is to get Kamagra, the most popular Viagra generic. The price of Kamagra is more reasonable then the price of Viagra. You can order Kamagra from online pharmacy as the over the counter medicine. However, be aware to buy Kamagra only from trusted pharmacy like is.

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